Across TCGA pan-cancer cohorts, ZNF859P RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of ZNF859P’s most consistent transcriptional readouts.
The strongest signal is observed in thyroid carcinoma (THCA), where ZNF859P RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF859P is over-expressed in tumor, although a few such as THCA show the opposite, repressed pattern.
THCA are the cancer types where ZNF859P tumor–normal differential expression is most reproducible.