zinc finger protein 859, pseudogeneGenealiases: []
Q-omics provides the consensus-scored ZNF859P profile across patient tissues and cancer cell-line models. ZNF859P expression is associated with patient survival in 15 of 34 cancer types, with the highest sampling consensus in CESC. Among the 18 cancer types available for tumor–normal comparison, ZNF859P is differentially expressed in 1, with the highest sampling consensus in THCA. Additionally, ZNF859P RNA expression shows 6,265 significant protein co-abundance associations, with the highest sampling consensus in LSCC. Together, these results highlight CESC, THCA, and LSCC as cancer lineages where ZNF859P shows reproducible signals across survival, tumor–normal expression, and patient cross-omics analyses.
Every result is evaluated using two consensus scores. Sampling consensus measures how consistently a finding is reproduced within a cancer lineage across different conditions. Lineage consensus measures how broadly the result is shared across cancer types, distinguishing pan-cancer signals from lineage-specific patterns.
Premium analyses for ZNF859P — synthetic lethality, tumor antigen, and pembrolizumab response.
This table summarizes ZNF859P survival associations across molecular data types. ZNF859P RNA expression shows survival associations in the most cancer types (15). The rightmost column indicates the cancer type with the highest sampling consensus for each molecular layer.
This table ranks reproducible ZNF859P RNA expression–survival associations across cancer types. High ZNF859P expression shows unfavorable associations in CESC, LIHC, BRCA, LGG and THYM, but favorable associations in HNSC. The CESC Kaplan–Meier curve shows clear separation, with the high-expression group declining faster, consistent with the unfavorable association (log-rank p < 0.001). Together, the overview and detailed table identify CESC as the clearest survival context for ZNF859P RNA expression.
This table summarizes ZNF859P tumor–normal expression differences by data type. RNA shows broader differences across cancer types, with a lineage consensus of 1. The strongest signals are observed in THCA for RNA.
This table ranks reproducible tumor–normal expression differences for ZNF859P. A negative fold-change indicates higher expression in normal tissue than in tumor tissue. ZNF859P shows lower tumor expression in THCA. The THCA box plot shows higher ZNF859P RNA expression in normal versus tumor tissue (log2 FC = −0.020, t-test p = .003).
This table shows molecular features associated with ZNF859P in patient tissues and cancer cell lines. In patient samples, ZNF859P shows the broadest associations at the RNA and protein expression levels, with LSCC recurring as the lineage with the largest associated feature set.
