ZNF853

Across TCGA patient cohorts, ZNF853 mutation is significantly associated with the total protein of many other genes, with 5 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF853-associated genes across cancer lineages are p62 Lck ligand, Caspase-8, and MEK1. Each is linked with ZNF853 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF853-to-partner and partner-to-ZNF853 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p62 Lck ligand grouped by ZNF853-low versus ZNF853-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF853→partner) and Y-score (partner→ZNF853) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p62 Lck ligand →	+0.616	+3.009	<.001	.019	3	1
UCEC	Caspase-8 →	-0.303	-2.973	.028	.035	3	1
UCEC	MEK1 →	+0.490	+3.169	.014	.020	1	1
UCEC	ATM →	-0.747	-3.169	.002	.020	1	1
UCEC	BRCA2 →	-0.144	-2.992	.049	.036	1	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

p62 Lck ligand by ZNF853 expression — UCEC

Explore this box plot interactively →