ZNF85

Across TCGA patient cohorts, ZNF85 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF85-associated genes across cancer lineages are Notch1, Caspase-8, and 4E-BP1. Each is linked with ZNF85 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF85-to-partner and partner-to-ZNF85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF85-low versus ZNF85-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF85→partner) and Y-score (partner→ZNF85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.181	+2.232	<.001	.005	3	2
UCEC	Caspase-8 →	-0.248	-2.973	.008	<.001	3	2
UCEC	4E-BP1 →	+0.241	+3.169	.017	.018	3	2
UCEC	EGFR_pY1068 →	-0.192	-1.415	.041	.046	3	1
UCEC	eIF4E →	+0.210	+3.807	.007	<.001	2	2
UCEC	A-Raf_pS299 →	-0.094	-2.000	.036	.030	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Notch1 by ZNF85 expression — UCEC

Explore this box plot interactively →