ZNF85

Across TCGA cell cohorts, ZNF85 mutation is significantly associated with the mutation status of many other genes, with 682 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF85-associated genes across cancer lineages are CHD7, NFE2L3, and PROKR2. Each is linked with ZNF85 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF85-to-partner and partner-to-ZNF85 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CHD7 grouped by ZNF85-low versus ZNF85-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF85→partner) and Y-score (partner→ZNF85) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CHD7 →	+2.807	+4.247	.007	.007	1	2
LUNG_SCLC	NFE2L3 →	+5.502	+5.502	.003	.003	1	2
BLOOD_Lymphoma	PROKR2 →	+5.247	+4.429	.005	.005	1	2
BLOOD_Lymphoma	COL11A1 →	+3.025	+3.754	.006	.006	1	2
BLOOD_Lymphoma	UIMC1 →	+5.247	+4.429	.005	.005	1	2
LARGE_INTESTINE	MINDY4 →	+3.415	+3.215	.002	.002	1	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 682 associations by consensus.

CHD7 by ZNF85 expression — SKIN

Explore this box plot interactively →