ZNF835

Across TCGA patient cohorts, ZNF835 mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF835-associated genes across cancer lineages are c-Kit, Caveolin-1, and Claudin-7. Each is linked with ZNF835 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF835-to-partner and partner-to-ZNF835 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Kit grouped by ZNF835-low versus ZNF835-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF835→partner) and Y-score (partner→ZNF835) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Kit →	-0.523	-3.169	.046	.017	3	3
STAD	Caveolin-1 →	-0.773	-2.321	.023	.034	3	2
STAD	Claudin-7 →	+0.871	+3.169	.003	.018	2	3
UCEC	ERK2 →	+0.180	+3.807	.002	<.001	3	2
UCEC	Notch1 →	+0.154	+1.643	<.001	.003	3	2
UCEC	p38-MAPK_pT180_Y182 →	-0.287	-1.362	.040	.034	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

c-Kit by ZNF835 expression — SKCM

Explore this box plot interactively →