ZNF835

Across TCGA pan-cancer cohorts, ZNF835 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF835’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF835 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF835 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and LUAD are the cancer types where ZNF835 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF835 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	III,IV	−0.548	<.001	10	view →
COAD	Male	II,III,IV	−0.650	<.001	9	view →
LUAD	Female	All	−0.510	<.001	8	view →
BLCA	Male	IV	−1.880	.003	7	view →
UCEC	All	III,IV	−2.403	<.001	6	view →
KIRP	Male	II,III,IV	−0.845	<.001	6	view →
LUSC	Female	II,III,IV	−0.940	<.001	5	view →
STAD	All	All	−0.520	.007	5	view →
HNSC	Male	All	−0.404	.001	5	view →
LIHC	All	All	+0.356	<.001	5	view →
BRCA	All	All	−0.407	<.001	4	view →
KICH	Male	III,IV	−0.985	.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF835–THCA

Open the THCA breakdown →