ZNF804A

Across TCGA patient cohorts, ZNF804A mutation is significantly associated with the total protein of many other genes, with 88 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF804A-associated genes across cancer lineages are C-Raf, ACVRL1, and FoxM1. Each is linked with ZNF804A in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF804A-to-partner and partner-to-ZNF804A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZNF804A-low versus ZNF804A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF804A→partner) and Y-score (partner→ZNF804A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.200	+2.099	<.001	<.001	3	4
UCEC	ACVRL1 →	-0.099	-1.401	.013	.040	3	4
LUAD	FoxM1 →	+0.222	+1.536	.001	.013	3	3
LUAD	mTOR_pS2448 →	-0.103	-1.362	.045	.028	3	3
LUAD	ASNS →	+0.383	+1.652	.002	.004	3	3
UCEC	53BP1 →	+0.293	+1.662	.003	.010	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 88 associations by consensus.

C-Raf by ZNF804A expression — UCEC

Explore this box plot interactively →