ZNF804A

Across TCGA pan-cancer cohorts, ZNF804A RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated ZNF804A data layer compared with 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF804A RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF804A expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

HNSC, MESO, and LGG are the cancer types where ZNF804A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	III,IV	0.673	0.464	<.001	85	view →
MESO	OS	Median	II,III,IV	0.285	0.505	.006	62	view →
LGG	OS	Median	All	0.880	0.727	<.001	43	view →
UVM	DFS	Median	All	0.368	0.754	<.001	36	view →
SCLC	DFS	Median	All	0.181	0.399	.003	23	view →
LUSC	OS	Median	III,IV	0.304	0.819	.012	21	view →
KICH	OS	Tertile	II,III,IV	0.853	1.000	.013	19	view →
PAAD	DFS	Tertile	II,III,IV	0.545	0.352	.010	16	view →
THCA	OS	Median	II,III,IV	0.953	0.999	.004	13	view →
CESC	DFS	Quartile	III,IV	0.299	0.744	.015	12	view →
CHOL	DFS	Median	All	0.622	0.195	.019	12	view →
PRAD	DFS	Quartile	All	0.902	0.731	.022	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

ZNF804A–HNSC (DFS)

Open the HNSC breakdown →