ZNF780B

Across TCGA pan-cancer cohorts, ZNF780B Mutation is linked to patient survival in 5 of 34 cancer types, making it a survival-associated ZNF780B data layer compared with 25 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF780B Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF780B expression acts as an unfavorable survival marker, although some lineages such as UCEC and STAD show a favorable association.

UCEC, SCLC, and BLCA are the cancer types where ZNF780B Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	II,III,IV	0.895	0.427	.009	22	view →
SCLC	OS	Median	All	0.082	0.822	<.001	12	view →
BLCA	OS	Median	IV	0.063	0.576	<.001	6	view →
LIHC	DFS	Median	All	0.054	0.553	<.001	6	view →
STAD	OS	Median	IV	1.000	0.299	.047	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

ZNF780B–UCEC (DFS)

Open the UCEC breakdown →