ZNF780B

Across TCGA pan-cancer cohorts, ZNF780B RNA differs between tumor and matched normal tissue in 8 of 18 cancer types tested, making tumor–normal expression one of ZNF780B’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF780B RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF780B is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and LIHC are the cancer types where ZNF780B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF780B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.595	<.001	11	view →
THCA	Male	II,III,IV	−0.758	<.001	8	view →
LIHC	Female	II,III,IV	+0.603	<.001	6	view →
CHOL	Female	All	+1.830	<.001	3	view →
UCEC	All	All	−0.623	<.001	2	view →
KIRP	All	All	−0.463	<.001	2	view →
BRCA	Female	All	−0.197	.037	2	view →
KICH	All	All	−0.375	.038	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 8 strongest of 8 lineages.

ZNF780B–KIRC

Open the KIRC breakdown →