ZNF780B

Across TCGA patient cohorts, ZNF780B mutation is significantly associated with the RNA expression of many other genes, with 3,830 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF780B-associated genes across cancer lineages are INCENP, SKA1, and TSPAN7. Each is linked with ZNF780B in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF780B-to-partner and partner-to-ZNF780B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INCENP grouped by ZNF780B-low versus ZNF780B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF780B→partner) and Y-score (partner→ZNF780B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INCENP →	+0.391	+1.675	.007	.001	3	3
UCEC	SKA1 →	+0.623	+1.635	<.001	<.001	3	3
UCEC	TSPAN7 →	-0.928	-1.613	<.001	<.001	3	3
UCEC	FXN →	+0.382	+2.102	<.001	<.001	3	3
UCEC	CDKN3 →	+0.669	+1.635	<.001	<.001	3	3
UCEC	RFC5 →	+0.402	+1.645	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,830 associations by consensus.

INCENP by ZNF780B expression — UCEC

Explore this box plot interactively →