ZNF778

Across TCGA patient cohorts, ZNF778 mutation is significantly associated with the RNA expression of many other genes, with 3,089 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF778-associated genes across cancer lineages are RN7SL134P, USP9YP5, and PBK. Each is linked with ZNF778 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF778-to-partner and partner-to-ZNF778 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RN7SL134P grouped by ZNF778-low versus ZNF778-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF778→partner) and Y-score (partner→ZNF778) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RN7SL134P →	+0.072	+1.741	.006	.004	3	5
READ	USP9YP5 →	+0.163	+7.276	<.001	<.001	3	3
UCEC	PBK →	+0.861	+2.688	<.001	<.001	3	3
UCEC	HPF1 →	+0.539	+4.098	<.001	<.001	3	3
CESC	RNU6-15P →	+0.340	+4.364	.002	.006	3	3
BRCA	MIR8062 →	+0.387	+7.471	<.001	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,089 associations by consensus.

RN7SL134P by ZNF778 expression — UCEC

Explore this box plot interactively →