ZNF778

Across TCGA pan-cancer cohorts, ZNF778 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF778’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where ZNF778 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF778 is over-expressed in tumor, although a few such as KIRP and KIRC show the opposite, repressed pattern.

KIRP, LIHC, and KIRC are the cancer types where ZNF778 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF778 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−0.843	<.001	9	view →
LIHC	Female	II,III,IV	+0.508	<.001	9	view →
KIRC	Male	III,IV	−0.568	<.001	7	view →
BRCA	All	III,IV	−0.640	<.001	6	view →
CHOL	Male	All	+1.411	<.001	5	view →
LUSC	All	All	−0.305	.002	4	view →
KICH	Male	All	−0.551	.016	3	view →
BLCA	Male	IV	−0.695	.004	1	view →
ESCA	All	All	−0.453	.038	1	view →
LUAD	Male	III,IV	−0.413	.048	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF778–KIRP

Open the KIRP breakdown →