ZNF778

Across TCGA patient cohorts, ZNF778 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF778-associated genes across cancer lineages are GAPDH, PKC-a_pS657, and ATM. Each is linked with ZNF778 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF778-to-partner and partner-to-ZNF778 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ZNF778-low versus ZNF778-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF778→partner) and Y-score (partner→ZNF778) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.571	+1.938	.001	.001	3	3
UCEC	PKC-a_pS657 →	-0.286	-2.000	.023	.029	3	3
UCEC	ATM →	-0.516	-3.794	<.001	<.001	3	3
UCEC	Di-Ras3 →	-0.104	-2.687	.033	.005	3	3
UCEC	mTOR_pS2448 →	-0.127	-1.565	.009	.034	3	2
UCEC	mTOR →	-0.143	-1.415	.007	.043	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

GAPDH by ZNF778 expression — UCEC

Explore this box plot interactively →