ZNF776

Across TCGA pan-cancer cohorts, ZNF776 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF776 data layer compared with 27 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF776 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated ZNF776 expression acts as an unfavorable survival marker, although some lineages such as HNSC and UCEC show a favorable association.

HNSC, UCEC, and LUAD are the cancer types where ZNF776 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	All	0.919	0.615	.020	9	view →
UCEC	DFS	Tertile	II,III,IV	1.000	0.567	.033	4	view →
LUAD	OS	Median	II,III,IV	0.409	0.797	.013	4	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF776–HNSC (OS)

Open the HNSC breakdown →