ZNF776

Across TCGA pan-cancer cohorts, ZNF776 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF776’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where ZNF776 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF776 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

BLCA, THCA, and BRCA are the cancer types where ZNF776 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF776 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	III,IV	+0.745	<.001	10	view →
THCA	All	II,III,IV	−0.626	<.001	10	view →
BRCA	All	II,III,IV	+0.405	<.001	6	view →
HNSC	All	All	+0.340	.009	6	view →
CHOL	Female	All	+1.283	<.001	5	view →
STAD	All	II,III,IV	+0.569	.004	4	view →
KICH	All	All	−0.515	.001	4	view →
LIHC	All	All	+0.368	.001	4	view →
KIRP	Male	All	−0.463	.001	2	view →
ESCA	Female	All	+0.493	.015	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF776–BLCA

Open the BLCA breakdown →