ZNF76

Across TCGA patient cohorts, ZNF76 mutation is significantly associated with the RNA expression of many other genes, with 2,222 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF76-associated genes across cancer lineages are DUXAP3, MIR5587, and OR4F28P. Each is linked with ZNF76 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF76-to-partner and partner-to-ZNF76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DUXAP3 grouped by ZNF76-low versus ZNF76-high in LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF76→partner) and Y-score (partner→ZNF76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUAD	DUXAP3 →	+0.298	+4.631	<.001	.008	3	3
UCEC	MIR5587 →	+0.942	+2.406	<.001	<.001	3	2
LIHC	OR4F28P →	+0.049	+7.914	<.001	<.001	3	2
LIHC	FRG2HP →	+0.283	+6.149	<.001	.002	3	2
BLCA	ARMC8P1 →	+0.053	+4.799	<.001	.003	3	2
CESC	HMGB4 →	+0.010	+3.891	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,222 associations by consensus.

DUXAP3 by ZNF76 expression — LUAD

Explore this box plot interactively →