ZNF76

Across TCGA pan-cancer cohorts, ZNF76 RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated ZNF76 data layer compared with 6 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in small cell lung cancer (SCLC), where higher ZNF76 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF76 expression acts as an unfavorable survival marker, although some lineages such as SCLC and READ show a favorable association.

SCLC, READ, and PAAD are the cancer types where ZNF76 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SCLC	DFS	Median	II,III,IV	0.647	0.270	<.001	69	view →
READ	DFS	Tertile	All	0.963	0.650	.001	64	view →
PAAD	OS	Quartile	All	0.587	0.237	<.001	57	view →
ACC	DFS	Tertile	All	0.434	0.780	.001	51	view →
LIHC	DFS	Median	All	0.473	0.608	.001	36	view →
KICH	DFS	Quartile	II,III,IV	0.273	1.000	.001	31	view →
STAD	OS	Tertile	II,III,IV	0.602	0.740	.013	31	view →
SKCM	DFS	Median	III,IV	0.694	0.493	.002	21	view →
BLCA	OS	Tertile	II,III,IV	0.687	0.561	.024	17	view →
OV	OS	Median	All	0.736	0.647	.003	16	view →
MESO	OS	Median	III,IV	0.446	0.261	.012	14	view →
UCEC	OS	Median	III,IV	0.898	0.760	.014	14	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

ZNF76–SCLC (DFS)

Open the SCLC breakdown →