ZNF76

Across TCGA patient cohorts, ZNF76 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF76-associated genes across cancer lineages are Notch1, STAT3_pY705, and ATM. Each is linked with ZNF76 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF76-to-partner and partner-to-ZNF76 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by ZNF76-low versus ZNF76-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF76→partner) and Y-score (partner→ZNF76) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.248	+2.128	<.001	.009	3	2
UCEC	STAT3_pY705 →	-0.393	-1.700	<.001	.044	3	2
UCEC	ATM →	-0.629	-2.222	.001	.011	3	2
UCEC	Caspase-7-cleavedD198 →	+0.705	+3.604	.005	.001	3	2
UCEC	EGFR_pY1068 →	-0.304	-4.000	.004	<.001	3	1
UCEC	JNK2 →	+0.168	+2.331	.046	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Notch1 by ZNF76 expression — UCEC

Explore this box plot interactively →