Across TCGA cell cohorts, ZNF74 mutation is significantly associated with the RNA expression of many other genes, with 776 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF74-associated genes across cancer lineages are IL4, PRM2, and C3orf85. Each is linked with ZNF74 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF74-to-partner and partner-to-ZNF74 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF74→partner) and Y-score (partner→ZNF74) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	IL4 →	+1.483	+4.007	.001	.002	3	1
BLOOD_Leukemia	PRM2 →	+0.017	+3.969	.001	.009	3	1
BLOOD_Leukemia	C3orf85 →	+0.031	+4.539	<.001	<.001	3	1
BLOOD_Leukemia	RPS6KA6 →	+0.614	+3.623	<.001	.007	3	1
SKIN	BPIFA1 →	+0.046	+4.095	<.001	.009	3	1
SKIN	MFRP →	+0.026	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 776 associations by consensus.

Exploration

ZNF74 survival (RNA) · tumor vs normal (RNA) · all ZNF74 data types