ZNF728

Across TCGA patient cohorts, ZNF728 mutation is significantly associated with the total protein of many other genes, with 47 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF728-associated genes across cancer lineages are Rad50, Caspase-7-cleavedD198, and 4E-BP1_pT70. Each is linked with ZNF728 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF728-to-partner and partner-to-ZNF728 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ZNF728-low versus ZNF728-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF728→partner) and Y-score (partner→ZNF728) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.211	-2.459	.013	.019	3	2
UCEC	Caspase-7-cleavedD198 →	+0.728	+2.000	<.001	.003	3	2
UCEC	4E-BP1_pT70 →	+0.081	+1.906	.047	.015	3	2
LUSC	mTOR →	+0.255	+3.009	.038	.019	3	1
LUSC	NF-kB-p65_pS536 →	+0.625	+3.009	.001	.019	3	1
UCEC	eIF4G →	+0.242	+2.321	.027	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 47 associations by consensus.

Rad50 by ZNF728 expression — UCEC

Explore this box plot interactively →