ZNF716

Across TCGA patient cohorts, ZNF716 mutation is significantly associated with the RNA expression of many other genes, with 4,204 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF716-associated genes across cancer lineages are MED19, C15orf40, and PDAP1. Each is linked with ZNF716 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF716-to-partner and partner-to-ZNF716 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MED19 grouped by ZNF716-low versus ZNF716-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF716→partner) and Y-score (partner→ZNF716) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MED19 →	+0.260	+1.410	.007	.005	3	4
UCEC	C15orf40 →	+0.260	+1.432	<.001	.005	3	4
UCEC	PDAP1 →	+0.367	+4.032	<.001	<.001	3	4
COAD	COPS3 →	+0.571	+2.874	<.001	.001	3	4
UCEC	WRAP53 →	+0.446	+3.021	<.001	<.001	3	4
COAD	GTF2A2 →	+0.618	+3.498	<.001	.002	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,204 associations by consensus.

MED19 by ZNF716 expression — UCEC

Explore this box plot interactively →