ZNF709

Across TCGA patient cohorts, ZNF709 mutation is significantly associated with the total protein of many other genes, with 28 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF709-associated genes across cancer lineages are INPP4B, ASNS, and ATM. Each is linked with ZNF709 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF709-to-partner and partner-to-ZNF709 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ZNF709-low versus ZNF709-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF709→partner) and Y-score (partner→ZNF709) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.272	-2.502	.005	.001	3	2
UCEC	ASNS →	+0.384	+1.125	<.001	.033	3	2
UCEC	ATM →	-0.430	-1.847	.001	.007	3	2
UCEC	Caspase-7-cleavedD198 →	+0.451	+1.785	.011	.007	3	2
UCEC	4E-BP1 →	+0.315	+2.999	<.001	<.001	3	2
SKCM	Heregulin →	+0.237	+2.820	.004	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

INPP4B by ZNF709 expression — UCEC

Explore this box plot interactively →