ZNF708

Across TCGA cell cohorts, ZNF708 mutation is significantly associated with the RNA expression of many other genes, with 26 significant associations in total. URINARY_TRACT shows the largest number of these associations.

The most reproducible ZNF708-associated genes across cancer lineages are NOBOX, C22orf31, and HTR3D. Each is linked with ZNF708 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF708-to-partner and partner-to-ZNF708 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, NOBOX grouped by ZNF708-low versus ZNF708-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF708→partner) and Y-score (partner→ZNF708) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	NOBOX →	+0.072	+5.539	<.001	.003	3	2
URINARY_TRACT	C22orf31 →	+0.059	+4.217	<.001	.005	3	1
URINARY_TRACT	HTR3D →	+0.032	+5.044	<.001	<.001	3	1
URINARY_TRACT	COX8C →	+0.094	+4.217	<.001	.005	3	1
URINARY_TRACT	C1orf185 →	+0.097	+4.584	<.001	.002	3	1
URINARY_TRACT	CMA1 →	+0.053	+4.584	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

NOBOX by ZNF708 expression — BLOOD_Leukemia

Explore this box plot interactively →