ZNF704

Across TCGA patient cohorts, ZNF704 mutation is significantly associated with the RNA expression of many other genes, with 2,091 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF704-associated genes across cancer lineages are TYW3, FAM227B, and MIR4759. Each is linked with ZNF704 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF704-to-partner and partner-to-ZNF704 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TYW3 grouped by ZNF704-low versus ZNF704-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF704→partner) and Y-score (partner→ZNF704) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TYW3 →	+0.435	+3.628	.001	.001	3	2
UCEC	FAM227B →	+0.289	+2.455	.008	.001	3	2
BRCA	MIR4759 →	+1.293	+5.800	<.001	.003	3	2
CESC	ARHGAP22-IT1 →	+0.089	+5.201	<.001	.007	3	2
BRCA	UQCRFS1P3 →	+0.589	+5.148	<.001	.008	3	2
BRCA	RN7SKP68 →	+0.611	+5.441	<.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,091 associations by consensus.

TYW3 by ZNF704 expression — UCEC

Explore this box plot interactively →