ZNF704

Across TCGA pan-cancer cohorts, ZNF704 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF704’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZNF704 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF704 is over-expressed in tumor, although a few such as LUAD and THCA show the opposite, repressed pattern.

LUAD, THCA, and LUSC are the cancer types where ZNF704 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF704 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	−1.159	<.001	9	view →
THCA	All	II,III,IV	−0.853	<.001	8	view →
LUSC	All	II,III,IV	−1.095	<.001	6	view →
LIHC	Male	All	+1.052	<.001	6	view →
BRCA	Female	All	−0.594	<.001	6	view →
CHOL	All	All	+2.310	<.001	5	view →
KICH	All	All	−0.940	.001	4	view →
KIRP	Male	All	−0.879	<.001	4	view →
STAD	Female	All	−0.978	.038	2	view →
UCEC	All	All	−0.583	.001	2	view →
COAD	All	II,III,IV	−0.356	.028	2	view →
KIRC	Male	All	−0.337	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF704–LUAD

Open the LUAD breakdown →