ZNF704

Across TCGA patient cohorts, ZNF704 mutation is significantly associated with the total protein of many other genes, with 27 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF704-associated genes across cancer lineages are Annexin-1, 14-3-3_beta, and eIF4E. Each is linked with ZNF704 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF704-to-partner and partner-to-ZNF704 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Annexin-1 grouped by ZNF704-low versus ZNF704-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF704→partner) and Y-score (partner→ZNF704) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Annexin-1 →	+0.729	+2.720	<.001	.003	3	2
UCEC	14-3-3_beta →	-0.134	-3.558	<.001	.002	3	1
UCEC	eIF4E →	+0.201	+3.598	.017	.001	3	1
UCEC	A-Raf_pS299 →	-0.173	-2.807	<.001	.003	3	1
UCEC	ERK2 →	+0.209	+2.321	.006	.034	3	1
UCEC	GAPDH →	+0.537	+2.584	.012	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 27 associations by consensus.

Annexin-1 by ZNF704 expression — UCEC

Explore this box plot interactively →