ZNF701

Across TCGA patient cohorts, ZNF701 mutation is significantly associated with the total protein of many other genes, with 44 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF701-associated genes across cancer lineages are 14-3-3_beta, Acetyl-a-Tubulin-Lys40, and Myosin-IIa_pS1943. Each is linked with ZNF701 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF701-to-partner and partner-to-ZNF701 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by ZNF701-low versus ZNF701-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF701→partner) and Y-score (partner→ZNF701) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.133	-2.673	<.001	.005	3	2
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.415	+1.884	.033	.030	3	2
UCEC	Myosin-IIa_pS1943 →	+0.176	+2.598	.026	<.001	3	2
UCEC	p53 →	-0.322	-1.678	.030	.023	3	2
UCEC	ASNS →	+0.433	+3.459	.001	.005	3	2
UCEC	EGFR_pY1068 →	-0.343	-3.807	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 44 associations by consensus.

14-3-3_beta by ZNF701 expression — UCEC

Explore this box plot interactively →