Across TCGA patient cohorts, ZNF700 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF700-associated genes across cancer lineages are 4E-BP1, Akt_pT308, and Chk2_pT68. Each is linked with ZNF700 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF700-to-partner and partner-to-ZNF700 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF700→partner) and Y-score (partner→ZNF700) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.263	+2.321	<.001	.005	3	3
LUSC	Akt_pT308 →	+0.656	+2.179	.001	.035	3	2
LUSC	Chk2_pT68 →	+0.146	+2.879	.010	.030	3	2
UCEC	eIF4E →	+0.160	+4.013	.008	<.001	3	2
UCEC	ERK2 →	+0.129	+1.169	.019	.017	3	2
UCEC	MEK1 →	+0.381	+1.736	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

Exploration

ZNF700 survival (RNA) · tumor vs normal (RNA) · all ZNF700 data types