ZNF7

Across TCGA patient cohorts, ZNF7 mutation is significantly associated with the RNA expression of many other genes, with 3,651 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF7-associated genes across cancer lineages are MRPL49, FRRS1, and ABHD3. Each is linked with ZNF7 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF7-to-partner and partner-to-ZNF7 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MRPL49 grouped by ZNF7-low versus ZNF7-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF7→partner) and Y-score (partner→ZNF7) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MRPL49 →	+0.503	+3.906	<.001	<.001	3	2
UCEC	FRRS1 →	+0.624	+2.247	<.001	.001	3	2
UCEC	ABHD3 →	+0.667	+2.126	<.001	<.001	3	2
UCEC	PKN3 →	+0.641	+1.847	<.001	<.001	3	2
UCEC	GMEB1 →	+0.316	+2.115	.001	<.001	3	2
UCEC	ELOVL7 →	+0.678	+2.321	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,651 associations by consensus.

MRPL49 by ZNF7 expression — UCEC

Explore this box plot interactively →