ZNF691

Across TCGA pan-cancer cohorts, ZNF691 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of ZNF691’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where ZNF691 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF691 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, LSCC, and PDAC are the cancer types where ZNF691 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF691 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	All	III,IV	+0.523	<.001	9	view →
LSCC	Male	II,III,IV	+0.304	<.001	7	view →
PDAC	All	All	−0.258	.007	4	view →
HNSC	Male	IV	+0.831	.042	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

ZNF691–LUAD

Open the LUAD breakdown →