ZNF691

Across TCGA pan-cancer cohorts, ZNF691 RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated ZNF691 data layer compared with 2 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where higher ZNF691 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF691 expression acts as an unfavorable survival marker, although some lineages such as READ and LUAD show a favorable association.

LIHC, ACC, and LGG are the cancer types where ZNF691 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LIHC	DFS	Median	All	0.434	0.646	<.001	85	view →
ACC	DFS	Median	All	0.200	0.706	<.001	81	view →
LGG	DFS	Median	All	0.634	0.841	<.001	52	view →
READ	DFS	Tertile	II,III,IV	0.899	0.652	.002	43	view →
LUAD	OS	Median	All	0.846	0.724	.004	30	view →
KIRC	DFS	Median	All	0.685	0.566	.002	28	view →
THCA	DFS	Median	All	0.973	0.909	.004	15	view →
CHOL	DFS	Tertile	All	0.849	0.135	.001	15	view →
KIRP	DFS	Quartile	IV	0.036	0.685	.024	12	view →
SCLC	OS	Median	All	0.592	0.798	.005	11	view →
BLCA	OS	Quartile	IV	0.193	0.449	.019	11	view →
SKCM	OS	Median	II,III,IV	0.793	0.893	.010	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

ZNF691–LIHC (DFS)

Open the LIHC breakdown →