ZNF691

Across TCGA patient cohorts, ZNF691 mutation is significantly associated with the RNA expression of many other genes, with 736 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF691-associated genes across cancer lineages are RNA5SP516, BTBD10, and LIN7C. Each is linked with ZNF691 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF691-to-partner and partner-to-ZNF691 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP516 grouped by ZNF691-low versus ZNF691-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF691→partner) and Y-score (partner→ZNF691) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP516 →	+0.171	+2.937	.007	.009	3	2
UCEC	BTBD10 →	+0.594	+3.354	.001	.005	3	1
UCEC	LIN7C →	+0.669	+3.593	.002	.001	3	1
UCEC	DLAT →	+0.598	+2.700	.007	.006	3	1
UCEC	DHX37 →	+0.460	+2.512	.004	.009	3	1
UCEC	GPATCH11 →	+0.570	+3.732	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 736 associations by consensus.

RNA5SP516 by ZNF691 expression — UCEC

Explore this box plot interactively →