ZNF684

Across TCGA cell cohorts, ZNF684 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF684-associated genes across cancer lineages are GRM1, C14orf180, and LRRC3C. Each is linked with ZNF684 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF684-to-partner and partner-to-ZNF684 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GRM1 grouped by ZNF684-low versus ZNF684-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF684→partner) and Y-score (partner→ZNF684) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GRM1 →	+0.045	+3.750	<.001	.007	3	1
LARGE_INTESTINE	C14orf180 →	+0.144	+3.155	<.001	.008	3	1
LARGE_INTESTINE	LRRC3C →	+0.291	+3.921	<.001	.001	3	1
LARGE_INTESTINE	SMIM33 →	+0.574	+3.426	<.001	.007	3	1
LARGE_INTESTINE	CNR2 →	+0.124	+3.333	.001	.009	2	1
LARGE_INTESTINE	GPR27 →	+1.205	+3.424	<.001	.006	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

GRM1 by ZNF684 expression — LARGE_INTESTINE

Explore this box plot interactively →