Across TCGA patient cohorts, ZNF681 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF681-associated genes across cancer lineages are PCNA, TFRC, and ATM. Each is linked with ZNF681 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF681-to-partner and partner-to-ZNF681 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF681→partner) and Y-score (partner→ZNF681) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PCNA →	+0.241	+3.000	.001	<.001	3	5
UCEC	TFRC →	+0.519	+3.459	.004	.005	3	3
UCEC	ATM →	-0.556	-3.794	<.001	<.001	3	3
SKCM	Ku80 →	+0.261	+3.000	.041	.034	3	2
SKCM	Notch1 →	+0.313	+2.584	<.001	.011	3	2
SKCM	p70-S6K →	+0.252	+3.321	.022	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

Exploration

ZNF681 survival (RNA) · tumor vs normal (RNA) · all ZNF681 data types