Across TCGA cell cohorts, ZNF681 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,300 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF681-associated GO terms across cancer lineages are Negative regulation of heterochromatin organization, Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway, and Regulation of heterochromatin formation. Each is linked with ZNF681 in more than 10 cancer types. Because this analysis shows association rather than direction, both ZNF681-to-partner and partner-to-ZNF681 results are reported.

Each partner links to its own Q-omics profile.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF681→partner) and Y-score (partner→ZNF681) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	Negative regulation of heterochromatin organization →	+0.113	+0.922	.002	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Co-transcriptional mRNA 3'-end processing, cleavage and polyadenylation pathway →	+0.112	+0.675	.002	.008	3	10
CNS	Regulation of heterochromatin formation →	+0.078	+0.480	<.001	.001	2	11
LUNG_SCLC	Negative regulation of heterochromatin formation →	+0.113	+0.922	.002	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Co-transcriptional RNA 3'-end processing, cleavage and polyadenylation pathway →	+0.109	+0.601	<.001	.002	3	9
SOFT_TISSUE	Regulation of chromosome organization →	+0.044	+0.489	.005	.005	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,300 associations by consensus.

Exploration

ZNF681 survival (RNA) · tumor vs normal (RNA) · all ZNF681 data types