Across TCGA cell cohorts, ZNF681 mutation is significantly associated with the RNA expression of many other genes, with 6 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF681-associated genes across cancer lineages are OR52N2, UGT2B10, and SSTR4. Each is linked with ZNF681 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF681-to-partner and partner-to-ZNF681 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF681→partner) and Y-score (partner→ZNF681) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	OR52N2 →	+0.103	+4.392	.001	.003	3	1
SKIN	UGT2B10 →	+0.006	+4.977	<.001	.007	3	1
LUNG_NSCLC_LUAD	SSTR4 →	+0.165	+4.371	<.001	.005	3	1
LUNG_NSCLC_LUAD	DEFB136 →	+0.172	+5.266	<.001	.001	3	1
LARGE_INTESTINE	DEFA4 →	+0.026	+4.022	<.001	.006	3	1
LARGE_INTESTINE	BPIFA1 →	+0.138	+3.688	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Exploration

ZNF681 survival (RNA) · tumor vs normal (RNA) · all ZNF681 data types