ZNF680

Across TCGA patient cohorts, ZNF680 RNA expression is significantly associated with the protein abundance of many other proteins, with 16,663 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF680-associated proteins across cancer lineages are YWHAG, HDAC2, and MDC1. Each is linked with ZNF680 in more than 5 cancer types. Because this analysis shows association rather than direction, both ZNF680-to-partner and partner-to-ZNF680 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, ZNF680 versus YWHAG in CCRCC, with a Pearson correlation of 0.43.

RNA expression associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF680→partner) and Y-score (partner→ZNF680) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CCRCC	YWHAG →	+0.253	+0.537	<.001	<.001	3	6
LSCC	HDAC2 →	+0.453	+1.044	<.001	<.001	3	5
LUAD	MDC1 →	+0.350	+0.484	<.001	.003	3	5
GBM	GTF2I →	+0.358	+0.555	<.001	<.001	3	5
GBM	TNPO3 →	+0.275	+0.741	<.001	<.001	3	5
BRCA	EVI2B →	-0.698	-0.938	<.001	<.001	3	5

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,663 associations by consensus.

ZNF680 vs YWHAG — CCRCC

Explore this scatter interactively →