ZNF680

Across TCGA patient cohorts, ZNF680 mutation is significantly associated with the total protein of many other genes, with 52 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF680-associated genes across cancer lineages are Src, ATM, and 4E-BP1. Each is linked with ZNF680 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF680-to-partner and partner-to-ZNF680 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src grouped by ZNF680-low versus ZNF680-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF680→partner) and Y-score (partner→ZNF680) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src →	-0.204	-1.674	.004	.040	3	3
UCEC	ATM →	-0.467	-3.687	.002	.001	3	3
UCEC	4E-BP1 →	+0.284	+2.351	.002	.003	3	3
UCEC	eEF2 →	+0.402	+2.321	.001	.005	3	2
UCEC	INPP4B →	-0.294	-2.415	.008	.003	3	2
UCEC	MEK1 →	+0.277	+1.440	.029	.024	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 52 associations by consensus.

Src by ZNF680 expression — UCEC

Explore this box plot interactively →