ZNF680

Across TCGA cell cohorts, ZNF680 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,609 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF680-associated GO terms across cancer lineages are DNA biosynthetic process, Protein desumoylation, and Positive regulation of organelle assembly. Each is linked with ZNF680 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZNF680-to-partner and partner-to-ZNF680 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA biosynthetic process grouped by ZNF680-low versus ZNF680-high in PANCREAS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF680→partner) and Y-score (partner→ZNF680) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
PANCREAS	DNA biosynthetic process →	+0.079	+1.098	<.001	<.001	3	13
SOFT_TISSUE	Protein desumoylation →	+0.097	+0.793	<.001	<.001	3	12
SOFT_TISSUE	Positive regulation of organelle assembly →	+0.053	+0.829	<.001	<.001	3	12
BLOOD_Lymphoma	Microtubule organizing center organization →	+0.073	+1.581	<.001	<.001	3	12
PANCREAS	RNA export from nucleus →	+0.109	+0.940	<.001	<.001	3	12
BLOOD_Lymphoma	Positive regulation of isotype switching to IgG isotypes →	+0.159	+1.300	<.001	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,609 associations by consensus.

DNA biosynthetic process by ZNF680 expression — PANCREAS

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