ZNF680

Across TCGA cell cohorts, ZNF680 mutation is significantly associated with the RNA expression of many other genes, with 395 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF680-associated genes across cancer lineages are OR10W1, MS4A6E, and OR1L6. Each is linked with ZNF680 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF680-to-partner and partner-to-ZNF680 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR10W1 grouped by ZNF680-low versus ZNF680-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF680→partner) and Y-score (partner→ZNF680) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	OR10W1 →	+0.009	+2.754	<.001	.009	3	2
BONE	MS4A6E →	+0.040	+5.169	<.001	.004	3	1
BONE	OR1L6 →	+0.020	+5.169	<.001	.004	3	1
BONE	OR6C4 →	+0.020	+5.169	<.001	.004	3	1
BONE	C2orf80 →	+0.126	+5.169	<.001	.004	3	1
BONE	CXorf51A →	+0.090	+5.169	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 395 associations by consensus.

OR10W1 by ZNF680 expression — LARGE_INTESTINE

Explore this box plot interactively →