Across TCGA cell cohorts, ZNF677 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF677-associated genes across cancer lineages are MYL10, FAM237A, and SP8. Each is linked with ZNF677 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF677-to-partner and partner-to-ZNF677 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF677→partner) and Y-score (partner→ZNF677) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	MYL10 →	+0.177	+5.247	<.001	.001	3	2
BLOOD_Lymphoma	FAM237A →	+0.019	+4.643	<.001	.005	3	2
BLOOD_Myeloma	SP8 →	+0.196	+3.906	.007	.009	3	1
BLOOD_Myeloma	OR51E1 →	+0.014	+3.906	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	SPINK8 →	+0.127	+4.736	<.001	.009	3	1
BLOOD_Lymphoma	ADRB3 →	+0.037	+4.643	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

Exploration

ZNF677 survival (RNA) · tumor vs normal (RNA) · all ZNF677 data types