Across TCGA pan-cancer cohorts, ZNF676 Mutation is linked to patient survival in 12 of 34 cancer types, making it a survival-associated ZNF676 data layer compared with 20 for mass-spec protein.
The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF676 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF676 expression acts as an unfavorable survival marker, although some lineages such as UCEC and UCS show a favorable association.
UCEC, PAAD, and PCPG are the cancer types where ZNF676 Mutation most reproducibly stratifies survival.
Mutation survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.