Across TCGA pan-cancer cohorts, ZNF676 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of ZNF676’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF676 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF676 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.
KIRC, COAD, and LUSC are the cancer types where ZNF676 tumor–normal differential expression is most reproducible.
RNA tumor vs normal associations by lineage
Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF676 RNA (log2); positive values indicate higher expression in tumor. p-values are from the differential-expression test.