Across TCGA patient cohorts, ZNF676 mutation is significantly associated with the total protein of many other genes, with 78 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF676-associated genes across cancer lineages are GAPDH, p38-MAPK_pT180_Y182, and 4E-BP1. Each is linked with ZNF676 in more than 4 cancer types. Because this analysis shows association rather than direction, both ZNF676-to-partner and partner-to-ZNF676 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF676→partner) and Y-score (partner→ZNF676) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUSC	GAPDH →	+0.675	+2.709	.013	.003	3	5
UCEC	p38-MAPK_pT180_Y182 →	-0.343	-1.847	.014	.007	3	3
UCEC	4E-BP1 →	+0.307	+4.117	<.001	<.001	2	4
UCEC	STAT3_pY705 →	-0.409	-2.169	<.001	<.001	3	3
STAD	TFRC →	+0.734	+3.169	.016	.019	2	4
LUSC	Caspase-7-cleavedD198 →	+0.518	+2.009	.010	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 78 associations by consensus.

Exploration

ZNF676 survival (RNA) · tumor vs normal (RNA) · all ZNF676 data types