Across TCGA cell cohorts, ZNF665 mutation is significantly associated with the RNA expression of many other genes, with 96 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF665-associated genes across cancer lineages are KLHL34, DEFB125, and HAO1. Each is linked with ZNF665 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF665-to-partner and partner-to-ZNF665 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF665→partner) and Y-score (partner→ZNF665) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	KLHL34 →	+0.013	+4.906	<.001	.006	3	2
SKIN	DEFB125 →	+0.025	+4.415	.001	.007	3	2
BLOOD_Leukemia	HAO1 →	+0.018	+4.276	.006	.007	3	2
LUNG_NSCLC_LUAD	MAGEL2 →	+0.342	+2.830	.002	.005	3	2
OESOPHAGUS	NLRP8 →	+0.006	+4.906	<.001	.006	3	1
OESOPHAGUS	PPIAL4F →	+0.060	+4.906	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 96 associations by consensus.

Exploration

ZNF665 survival (RNA) · tumor vs normal (RNA) · all ZNF665 data types