ZNF664

Across TCGA patient cohorts, ZNF664 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF664-associated genes across cancer lineages are GAPDH, GSK3-a-b, and Shc_pY317. Each is linked with ZNF664 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF664-to-partner and partner-to-ZNF664 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by ZNF664-low versus ZNF664-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF664→partner) and Y-score (partner→ZNF664) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.693	+3.459	.002	.005	3	2
UCEC	GSK3-a-b →	+0.146	+3.321	.011	.010	3	2
UCEC	Shc_pY317 →	-0.289	-3.584	<.001	.002	3	2
UCEC	VEGFR2 →	+0.262	+2.235	.038	.006	3	2
UCEC	c-Jun_pS73 →	-0.184	-3.449	.006	.005	3	2
UCEC	Di-Ras3 →	-0.240	-3.308	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

GAPDH by ZNF664 expression — UCEC

Explore this box plot interactively →