ZNF664

Across TCGA pan-cancer cohorts, ZNF664 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of ZNF664’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF664 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF664 is over-expressed in tumor, although a few such as THCA and KIRC show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where ZNF664 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF664 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.842	<.001	11	view →
BLCA	Female	III,IV	+0.904	<.001	10	view →
LIHC	Female	II,III,IV	+1.190	<.001	9	view →
STAD	All	II,III,IV	+0.808	<.001	9	view →
THCA	Male	All	−0.655	<.001	8	view →
BRCA	All	II,III,IV	+0.365	<.001	8	view →
UCEC	All	All	+0.614	.011	6	view →
KIRC	Male	II,III,IV	−0.522	<.001	6	view →
CHOL	Male	All	+2.193	<.001	5	view →
PRAD	All	All	+0.553	<.001	2	view →
KIRP	Female	II,III,IV	+0.500	.037	2	view →
COAD	Male	All	+0.332	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

ZNF664–HNSC

Open the HNSC breakdown →