ZNF66

Across TCGA cell cohorts, ZNF66 mutation is significantly associated with the RNA expression of many other genes, with 17 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF66-associated genes across cancer lineages are PITX3, REG1B, and OR10W1. Each is linked with ZNF66 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF66-to-partner and partner-to-ZNF66 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PITX3 grouped by ZNF66-low versus ZNF66-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF66→partner) and Y-score (partner→ZNF66) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PITX3 →	+0.223	+3.643	<.001	.005	3	1
LARGE_INTESTINE	REG1B →	+1.730	+3.196	.008	.007	3	1
LARGE_INTESTINE	OR10W1 →	+0.012	+3.977	<.001	.001	3	1
LARGE_INTESTINE	C14orf180 →	+0.161	+3.155	<.001	.008	3	1
LARGE_INTESTINE	CD300H →	+0.036	+4.415	<.001	<.001	3	1
BLOOD_Lymphoma	ZC2HC1B →	+0.142	+3.736	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 17 associations by consensus.

PITX3 by ZNF66 expression — LARGE_INTESTINE

Explore this box plot interactively →